Abstract Morphine (M), morphine 3-glucuronide (M3G) and morphine 6-glucuronide (M6G)
were subcutaneously administered at 10 mg/kg in three groups of six awake rats. A …

Microdialysis was used to sample morphine 6-glucuronide (M6G) and morphine in striatal
extracellular fluid after systemic administration in awake, freely moving rats. Morphine or …

Misra et al.(1971) found that 1 h after a single subcutaneous injection of [N-Me-l4C1-
morphine into the rat, three radioactive compounds could be extracted from the cerebral …

In this report, we describe an HPLC with electrochemical detection assay for the
simultaneous measurement of levels of morphine, serotonin, 5‐hydroxyindole‐3‐acetic acid …

The pharmacokinetics (uptake and elimination) and pharmacodynamics (biochemical effects
on monoamine systems) of morphine in the CNS were investigated concurrently. ICR mice …

Regional morphine accumulation was examined in 8 brain areas (cerebral cortex,
hippocampus, striatum, midbrain, hypothalamus, thalamus, medulla oblongata and …

We investigated whether capacity-limited transport processes were involved in morphine
and morphine-6-β-d-glucuronide (M6G) neuropharmacokinetics, at the level of the blood …

A simple procedure for the simultaneous determination of morphine and monoamine
transmitters was developed. The procedure consisted of (1) n-butanol extraction and (2) …

Morphine has been determined in serum, cerebrospinal fluid (csf) and in five brain regions
in the rat after a single intravenous dose, using high performance liquid chromatography …

The unbound concentration of morphine in striatum of rats was estimated during a constant
rate infusion of morphine 14 μmol/h∗ kg, by use of the microdialysis technique and …