Neuropathological studies revealed the propagation of amyotrophic lateral sclerosis (ALS)
in a sequence of four separate disease-related regional patterns. Diffusion tensor imaging …

Objective Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a
dissemination in a regional sequence in four anatomically defined patterns. The aim of this …

Several quantitative magnetic resonance imaging (MRI) techniques have been proposed to
investigate microstructural tissue changes in amyotrophic lateral sclerosis (ALS) including …

Background and objective The neuropathology of amyotrophic lateral sclerosis (ALS)
follows a regional distribution pattern in the brain with four stages. Using diffusion tensor …

Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for
cerebral microstructural alterations in neurodegenerative diseases is under investigation. In …

Importance of the field: With the emergence of therapeutic candidates for the incurable and
rapidly progressive neurodegenerative condition of amyotrophic lateral sclerosis (ALS), it …

Amyotrophic lateral sclerosis (ALS) is the most prevalent type of motor neuron disease
(MND) and is diagnosed with a delay from the first appearance of symptoms. Surrogate …

Previous diffusion tensor imaging (DTI) studies have shown white matter pathology in
amyotrophic lateral sclerosis (ALS), predominantly in the motor pathways. Further these …

Objective markers of disease sensitive to the clinical activity, symptomatic progression, and
underlying substrates of neurodegeneration are highly coveted in amyotrophic lateral …

Objective Cell structural changes are one of the main features observed during the
development of amyotrophic lateral sclerosis (ALS). In this work, we propose the use of …