The neurodegenerative disorder amyotrophic lateral sclerosis (ALS) is characterized by the
progressive loss of upper and lower motor neurons, with pathological involvement of …

Diffusion tensor spectroscopy (DTS) combines features of magnetic resonance spectroscopy
and diffusion tensor imaging and permits evaluating cell-type specific properties of …

In amyotrophic lateral sclerosis (ALS), magnetic resonance imaging (MRI) allows
investigation at the microstructural level, employing techniques able to reveal white matter …

We investigated 17 patients with sporadic amyotrophic lateral sclerosis (ALS) using voxel-
based morphometry (VBM) and voxel-based analysis of diffusion tensor images (DTI) at …

Diffusion tensor imaging can identify amyotrophic lateral sclerosis-associated patterns of
brain alterations at the group level. Recently, a neuropathological staging system for …

Background Recent advances in MRI acquisitions and image analysis have increased the
utility of neuroimaging in understanding disease-related changes. In this work, we aim to …

Background and aims Considering the great heterogeneity of amyotrophic lateral sclerosis
(ALS), the identification of accurate prognostic predictors is fundamental for both the clinical …

BACKGROUND AND PURPOSE: ALS leads to macrostructural (ie, cortical atrophy and
hyperintensities along the corticospinal tract) and microstructural (ie, gray matter intrinsic …

Extensive pathological evidence indicates that axonal degeneration represents an early and
critical event in amyotrophic lateral sclerosis (ALS). Unfortunately, few MRI studies have …

ABSTRACT INTRODUCTION In order to obtain detailed information on disease‐associated
changes in the integrity of cerebral white matter (WM), complementary image analysis (CIA) …