Degeneration of motor neurons and their associated axons is a hallmark of amyotrophic
lateral sclerosis, but reliable noninvasive lesion detection is lacking. In vivo diffusion tensor …

BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) allows direct visualization
and volumetric analysis of the corticospinal tract (CST). The purpose of this study was to …

Diffusion tensor imaging (DTI) for assessing ALS-associated white matter alterations has still
not reached the level of a neuroimaging biomarker. Since large-scale multicentre DTI …

Objectives To assess microstructural alterations in white matter (WM) in amyotrophic lateral
sclerosis (ALS) using diffusion tensor imaging (DTI). Methods DTI data were collected from …

Patients with amyotrophic lateral sclerosis (ALS) can present with varying degrees of upper
motor neuron (UMN) and lower motor neuron dysfunction. Previous diffusion tensor imaging …

Objectives To explore the sensitivity of potential DTI-based biomarkers in detecting
microstructural changes for whole-brain white matter in early stage amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease, which primarily
targets the motor system. The structural integrity of the motor network and the way it is …

A sequential transaxonal disease spread of amyotrophic lateral sclerosis (ALS)-associated
TDP-43 pathology in four stages has been defined by post-mortem data, which have been …

Purpose This paper aims to analyze the contribution of mean diffusivity (MD), axial diffusivity
(AD), and radial diffusivity (RD) in the detection of microstructural abnormalities in …

Purpose Diagnosis of amyotrophic lateral sclerosis (ALS) can be difficult from clinical
symptoms alone. Diffusion tensor imaging (DTI) has been suggested as an adjunct …