Although the pathogenesis of amyotrophic lateral sclerosis (ALS) is uncertain, there is
mounting neuroimaging evidence to suggest a mechanism involving the degeneration of …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of motor neurons in the
brain and spinal cord. Accumulation of misfolded proteins is central in the pathogenesis of …

Previous neuroimaging studies have revealed that both gray matter (GM) and white matter
(WM) are altered in several morphological aspects in amyotrophic lateral sclerosis (ALS) …

Objective: To investigate changes in the diffusion tensor imaging measures, axial diffusivity
and radial diffusivity, in addition to the more commonly used fractional anisotropy and mean …

In this study, we used an automated segmentation of regions of interest and co-registration
to diffusion tensor imaging (DTI) images to investigate whether microstructural abnormalities …

Background: Histopathological studies of amyotrophic lateral sclerosis (ALS) are of end
stage disease. Diffusion tensor imaging (DTI) provides the opportunity to investigate …

Materials and Methods: Twenty-one patients with ALS and 13 age-matched controls
received 1.5 T DTI and three-dimensional multi-voxel MRS. Fractional anisotropy (FA) …

Aims To evaluate microstructural impairment in the thalamus and thalamocortical
connectivity using neurite orientation dispersion and density imaging (NODDI) in …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily characterized
by the progressive impairment of motor functions. However, a significant portion of affected …

Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, is a motor neuron
disease characterized by progressive degeneration of upper motor neuron (UMN) and lower …