Primary lateral sclerosis (PLS) has been regarded as a rare, extreme form of amyotrophic
lateral sclerosis (ALS). Like ALS, it is a clinical diagnosis without established biomarkers …

Objective: The clinical diagnosis of primary lateral sclerosis can only be made after upper
motor neuron symptoms have progressed for several years without developing lower motor …

Magnetic resonance imaging measures have been proposed as objective markers to study
upper motor neuron loss in motor neuron disorders. Cross-sectional studies have identified …

Purpose To establish the relationship between ALS histopathology and quantitative MRI
metrics. Materials and Methods ALS patients (N= 8) in advanced stages of the disease were …

BACKGROUND AND PURPOSE: Various lines of evidence implicate cerebral involvement
beyond the motor cortex in ALS, including the cingulate gyrus and the thalamus. The …

MRI of the brain and spinal cord was performed in 21 patients with amyotrophic lateral
sclerosis (ALS), 8 normal volunteers and 16 neurological disease controls. High signal was …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor
neurons in the cerebral cortex, brainstem, and spinal cord, brain regions in which …

There is no reliable objective indicator for upper motor neuron dysfunction in amyotrophic
lateral sclerosis (ALS). To determine the clinical significance and potential utility of magnetic …

Our aim was to evaluate the location and extent of white matter involvement in patients with
amyotrophic lateral sclerosis (ALS) using diffusion-tensor magnetic resonance imaging …

There is an ongoing discussion whether ALS is primarily a disease of upper motor neurons
or lower motor neurons. We undertook a review to assess how new insights have …