Purpose To investigate the patterns of cortical thinning and white matter tract damage in
patients with lower motor neuron (LMN)–predominant disease compared with healthy …

Primary lateral sclerosis (PLS) bears close resemblance to cases of amyotrophic lateral
sclerosis (ALS) presenting with spasticity, but histopathological studies have shown …

Aim To investigate whether primary lateral sclerosis (PLS) represents part of the
amyotrophic lateral sclerosis–frontotemporal dementia (ALS–FTD) spectrum of diseases …

Amyotrophic lateral sclerosis (ALS) is a progressive and intractable neurodegenerative
disease of human motor system characterized by progressive muscular weakness and …

BACKGROUND AND PURPOSE: In the search for a diagnostic marker in ALS, we focused
our attention on the hyperintense signal intensity in T1 MTC MR images along the CST …

Objectives Primary lateral sclerosis (PLS) is commonly considered as a motor neuron
disease (MND) variant which almost exclusively affects upper motor neurons (UMN). There …

Primary lateral sclerosis is a sporadic disorder characterized by slowly progressive
corticospinal dysfunction. Primary lateral sclerosis differs from amyotrophic lateral sclerosis …

Studies involving diffusion tensor imaging (DTI) of amyotrophic lateral sclerosis (ALS) with
whole-brain voxel-based analysis yielded variable findings. A systematic review was …

Diagnosis, stratification and monitoring of disease progression in amyotrophic lateral
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …

Background and aims Considering the great heterogeneity of amyotrophic lateral sclerosis
(ALS), the identification of accurate prognostic predictors is fundamental for both the clinical …