The uptake of [N-14 C methyl] morphine into rat, mouse, or guinea pig brain slices does not
meet the criteria for an active transport process.(1) Methods are described for the extraction …

The role played by the active or passive transport of narcotic analgesics in the action of
these drugs on the central nervous system is not clear. Choroid plexus tissue in vitro …

The uptake of [n-methyl 14 C] morphine by mouse kidney slices was saturable, reversible,
temperature-and pH-dependent, and was inhibited by strong metabolic poisons and by …

The transport of morphine from the systemic circulation into the perfused cerebrospinal fluid
was studied while the free morphine plasma concentration was kept constant with …

The binding of morphine to brainstem slices was studied with nanomolar concentrations of
(3H)-morphine. Rat brainstem slices were incubated at 35 degrees C and immediately …

Misra et al.(1971) found that 1 h after a single subcutaneous injection of [N-Me-l4C1-
morphine into the rat, three radioactive compounds could be extracted from the cerebral …

In order to determine the possible contribution of altered distribution of morphine in the
morphine tolerance process, the distribution of morphine was studied in brain regions and …

Materials and Methods Animals. The subjects were male Wistar rats (TNO, Zeist, the
Netherlands), weighing approximately 220 g. They were maintained in a temperature …

Rats were injected with morphine-6 (3) H diluted with increasing amounts of non-
radiolabelled morphine. The entry of the isotope into the brain and various tissues was …

Previously it was demonstrated that intravenously administered morphine produced greater
analgesic but lower hyperthermic responses to morphine in 24-week-old rats in comparison …