Extramotor damage is associated with cognition in primary lateral sclerosis patients

E Canu, F Agosta, S Galantucci, A Chio, N Riva… - PLoS …, 2013 - journals.plos.org
Objectives This is a cross-sectional study aimed at investigating cognitive performances in
patients with primary lateral sclerosis (PLS) and using diffusion tensor (DT) magnetic …

Imaging findings associated with cognitive performance in primary lateral sclerosis and amyotrophic lateral sclerosis

A Meoded, JY Kwan, TL Peters, ED Huey… - Dementia and geriatric …, 2013 - karger.com
Introduction: Executive dysfunction occurs in many patients with amyotrophic lateral
sclerosis (ALS), but it has not been well studied in primary lateral sclerosis (PLS). The aims …

Extra-motor cerebral changes and manifestations in primary lateral sclerosis

E Finegan, SLH Shing, RH Chipika, KM Chang… - Brain imaging and …, 2021 - Springer
Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …

Microstructural White Matter Changes Underlying Cognitive and Behavioural Impairment in ALS – An In Vivo Study Using DTI

E Kasper, C Schuster, J Machts, J Kaufmann, D Bittner… - PloS one, 2014 - journals.plos.org
Background A relevant fraction of patients with amyotrophic lateral sclerosis (ALS) exhibit a
fronto-temporal pattern of cognitive and behavioural disturbances with pronounced deficits …

Assessing the correlation between grey and white matter damage with motor and cognitive impairment in multiple sclerosis patients

E Sbardella, N Petsas, F Tona, L Prosperini, E Raz… - PloS one, 2013 - journals.plos.org
Background Multiple sclerosis (MS) is characterized by demyelinating and degenerative
processes within the central nervous system. Unlike conventional MRI, new advanced …

NODDI, diffusion tensor microstructural abnormalities and atrophy of brain white matter and gray matter contribute to cognitive impairment in multiple sclerosis

P Preziosa, E Pagani, A Meani, O Marchesi, L Conti… - Journal of …, 2023 - Springer
Background Pathologically specific MRI measures may elucidate in-vivo the heterogeneous
processes contributing to cognitive impairment in multiple sclerosis (MS). Purpose Using …

[HTML][HTML] Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling

E Finegan, SLH Shing, RH Chipika, MA Doherty… - NeuroImage: Clinical, 2019 - Elsevier
Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …

Brain MR imaging in patients with lower motor neuron–predominant disease

EG Spinelli, F Agosta, PM Ferraro, N Riva, C Lunetta… - Radiology, 2016 - pubs.rsna.org
Purpose To investigate the patterns of cortical thinning and white matter tract damage in
patients with lower motor neuron (LMN)–predominant disease compared with healthy …

Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: a combined voxel-based …

F Christidi, E Karavasilis, F Riederer, I Zalonis… - Brain imaging and …, 2018 - Springer
The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients
show structural changes within but also beyond the motor cortex and corticospinal tract and …

Limbic pathway correlates of cognitive impairment in multiple sclerosis

Z Keser, KM Hasan, B Mwangi, RE Gabr… - Journal of …, 2017 - Wiley Online Library
ABSTRACT BACKGROUND AND PURPOSE Distinct injuries to various limbic white matter
pathways have been reported to be associated with different aspects of cognitive …