Buprenorphine is a derivative of the morphine alkaloid thebaine. The plasma elimination
half‐life of buprenorphine is three times longer than that of the active metabolite …

Buprenorphine is an opioid analgesic, derived from thebaine. Buprenorphine was initially
classified as a" mixed agonist-antagonist analgesic" or a narcotic antagonist analgesic. The …

Buprenorphine is a potent opioid analgesic clinically used to treat moderate to severe pain.
The present study assessed its analgesic efficacy in a broad range of rodent models of acute …

What is known and objective Based on in vitro assays and select animal models,
buprenorphine is commonly called a 'partial agonist'. An implication is that it should produce …

The agonist-antagonist opioid analgesics are a heterogeneous group of drugs with
moderate to strong analgesic activity comparable to that of the pure agonist opioids such as …

Pharmacological properties of buprenorphine were studied in comparison with those of
morphine and pentazocine. Buprenorphine was more potent than morphine and …

The historical background leading to the current use of buprenorphine as an analgesic and
its role in the management of opioid dependence is summarized. The popular description of …

Despite the increasing clinical use of transdermal buprenorphine, questions have persisted
about the possibility of a ceiling effect for analgesia, its combination with other μ‐opioid …

The relationships between plasma or brain concentrations and analgesic effects of both
buprenorphine(BN) and an active metabolite, norbuprenorphine(NBN), were investigated in …

Pharmacological properties of buprenorphine were compared with those of morphine and
pentazocine. Buprenorphine scarcely showed any effects on spontaneous EEGs and sleep …