Impaired corticopontocerebellar tracts underlie pseudobulbar affect in motor neuron disorders

MK Floeter, R Katipally, MP Kim, O Schanz… - Neurology, 2014 - AAN Enterprises
Objective: The objectives of the study were (1) to determine the prevalence and
characteristics of pseudobulbar affect (PBA) in patients with primary lateral sclerosis (PLS) …

[HTML][HTML] Radiological correlates of pseudobulbar affect: Corticobulbar and cerebellar components in primary lateral sclerosis

M Tahedl, EL Tan, WF Siah, JC Hengeveld… - Journal of the …, 2023 - Elsevier
Introduction Pseudobulbar affect (PBA) is a distressing symptom of a multitude of
neurological conditions affecting patients with a rage of neuroinflammatory, neurovascular …

Resting state fMRI analysis of pseudobulbar affect in Amyotrophic Lateral Sclerosis (ALS): motor dysfunction of emotional expression

F Trojsi, F Di Nardo, G D'Alvano, G Caiazzo… - Brain imaging and …, 2023 - Springer
Pseudobulbar affect (PBA), referring to exaggerated or inappropriate episodes of laughing
and/or crying without an apparent motivating stimulus, has been mainly attributed to bilateral …

Neuroanatomy of pseudobulbar affect: a quantitative MRI study in multiple sclerosis

O Ghaffar, L Chamelian, A Feinstein - Journal of neurology, 2008 - Springer
Pseudobulbar affect (PBA) is defined as episodes of involuntary crying, laughing, or both in
the absence of a matching subjective mood state. This neuropsychiatric syndrome can be …

Laughter, crying and sadness in ALS

NJ Thakore, EP Pioro - Journal of Neurology, Neurosurgery & …, 2017 - jnnp.bmj.com
Background Pseudobulbar affect (PBA) is prevalent in amyotrophic lateral sclerosis (ALS),
but there is limited information on its associations and course. Objectives Explore …

Brain responses to verbal stimuli among multiple sclerosis patients with pseudobulbar affect

G Haiman, H Pratt, A Miller - Journal of the neurological sciences, 2008 - Elsevier
PURPOSE: To characterize the brain activity and associated cortical structures involved in
pseudobulbar affect (PBA), a condition characterized by uncontrollable episodes of …

The epidemiology and pathophysiology of pseudobulbar affect and its association with neurodegeneration

RR King, JP Reiss - Degenerative neurological and neuromuscular …, 2013 - Taylor & Francis
Pseudobulbar affect is a disorder resulting from neurologic damage manifesting as sudden,
stereotyped affective outbursts that are not reflective of internal emotion. A literature review …

[HTML][HTML] Neuronal dysregulation in stroke-associated pseudobulbar affect (PBA): diagnostic scales and current treatment options

PA Lapchak - Journal of neurology & neurophysiology, 2015 - ncbi.nlm.nih.gov
Until recently there was little understanding of the exact pathophysiology and treatment
choices for stroke patients with Pseudobulbar affect (PBA). PBA is typically characterized by …

Pseudobulbar affect: prevalence and quality of life impact in movement disorders

RE Strowd, MS Cartwright, MS Okun, I Haq… - Journal of …, 2010 - Springer
Pseudobulbar affect (PBA) is an affective disinhibition syndrome characterized by sudden,
involuntary outbursts of inappropriate crying or laughing. We have previously reported the …

Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis

A Lenka, M Ingalhalikar, A Shah, J Saini… - Neurology, 2020 - AAN Enterprises
Objective The objective of the current study was to compare the microstructural integrity of
the white matter (WM) tracts in patients having Parkinson disease (PD) with and without …