The influence of chemical modifications on the fragmentation behavior of fentanyl and fentanyl‐related compounds in electrospray ionization tandem mass …

JT Davidson, ZJ Sasiene… - Drug Testing and …, 2020 - Wiley Online Library
Fentanyl is a synthetic opioid that has been approved by the FDA as a general anesthetic
because of its rapid onset and high potency. However, since 2013 an opioid epidemic …

Fentanyl: a whole new world?

RL Rothberg, K Stith - Journal of Law, Medicine & Ethics, 2018 - cambridge.org
This article seeks to document the latest danger in the opioid crisis: fentanyl and related
synthetic opioids. Fifty times more potent than pure heroin, cheaper to manufacture in …

[HTML][HTML] U-47700 and its analogs: non-fentanyl synthetic opioids impacting the recreational drug market

MH Baumann, G Tocco, DM Papsun, AL Mohr… - Brain sciences, 2020 - mdpi.com
The recreational use of opioid drugs is a global threat to public health and safety. In
particular, an epidemic of opioid overdose fatalities is being driven by illicitly manufactured …

Structurally diverse fentanyl analogs yield differential locomotor activities in mice

NB Varshneya, DM Walentiny, DL Stevens… - Pharmacology …, 2023 - Elsevier
Synthetic narcotics have been implicated as the single greatest contributor to increases in
opioid-related fatalities in recent years. This study evaluated the effects of nine fentanyl …

Non-fentanyl new synthetic opioids–An update

JB Zawilska, P Adamowicz, M Kurpeta… - Forensic science …, 2023 - Elsevier
Background New synthetic opioids (NSO) constitute one of the fastest-growing group of New
Psychoactive Substances, which emerged on the illicit drug marker in the second half of …

Toxicological and pharmacological characterization of novel cinnamylpiperazine synthetic opioids in humans and in vitro including 2-methyl AP-237 and AP-238

MF Fogarty, MM Vandeputte, AJ Krotulski… - Archives of …, 2022 - Springer
The recent scheduling actions of fentanyl-related substances in both the United States and
China have sparked the emergence and proliferation of other generations of “legal” opioids …

A 2017–2019 update on acute intoxications and fatalities from illicit fentanyl and analogs

P Brunetti, F Pirani, J Carlier, R Giorgetti… - Journal of Analytical …, 2021 - academic.oup.com
The aim of this review was to report the most recent cases of acute intoxication, fatalities and
“driving under the influence” cases, involving illicit fentanyl and its newest analogs. When …

[HTML][HTML] An expanding world of novel psychoactive substances: opioids

JB Zawilska - Frontiers in psychiatry, 2017 - frontiersin.org
The abuse of novel psychoactive substances (NPS) has been increasing dramatically
worldwide since late 2000s. By the end of 2015, more than 560 NPS had been reported to …

[HTML][HTML] Fentanyl and other opioid use disorders: treatment and research needs

ND Volkow, C Blanco - American Journal of Psychiatry, 2023 - Am Psychiatric Assoc
The opioid overdose epidemic, which has been markedly exacerbated by fentanyl,
highlights the urgency for psychiatrists to be well versed on the proper screening and …

Fentanyl absorption, distribution, metabolism, and excretion: Narrative review and clinical significance related to illicitly manufactured fentanyl

HE Bird, AS Huhn, KE Dunn - Journal of addiction medicine, 2023 - journals.lww.com
Objectives This narrative review summarizes literature on pharmaceutical fentanyl's
absorption, distribution, metabolism, and excretion patterns to inform research on illicitly …