Background There is an ongoing debate whether primary lateral sclerosis (PLS) should be
regarded as an independent disease entity separate from amyotrophic lateral sclerosis …

Background After the demonstration of a corticoefferent propagation pattern in amyotrophic
lateral sclerosis (ALS) by neuropathological studies, this concept has been used for in vivo …

Several quantitative magnetic resonance imaging (MRI) techniques have been proposed to
investigate microstructural tissue changes in amyotrophic lateral sclerosis (ALS) including …

A sequential transaxonal disease spread of amyotrophic lateral sclerosis (ALS)-associated
TDP-43 pathology in four stages has been defined by post-mortem data, which have been …

Objective Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a
dissemination in a regional sequence in four anatomically defined patterns. The aim of this …

Our objective was to explore the value of additional MR contrasts in elucidating the
decrease in fractional anisotropy (FA) as has been observed in the corticospinal tracts (CST) …

Objective: While the hallmark of amyotrophic lateral sclerosis (ALS) is corticospinal tract in
combination with lower motor neuron degeneration, the clinical involvement of both …

The aim of this work was to investigate white-matter microstructural changes within and
outside the corticospinal tract in classical amyotrophic lateral sclerosis (ALS) and in lower …

In amyotrophic lateral sclerosis (ALS), magnetic resonance imaging (MRI) allows
investigation at the microstructural level, employing techniques able to reveal white matter …

Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for
cerebral microstructural alterations in neurodegenerative diseases is under investigation. In …