Neuropathological studies revealed the propagation of amyotrophic lateral sclerosis (ALS)
in a sequence of four separate disease-related regional patterns. Diffusion tensor imaging …

Criteria for assessing upper motor neuron pathology in lower motor neuron disease (LMND)
still remain major issues in clinical diagnosis. This study was designed to investigate …

BACKGROUND: MR diffusion tensor imaging (DTI) appears to be a powerful method to
investigate the neuronal and axonal fibre distribution in the human brain. Changes in …

Patients with amyotrophic lateral sclerosis (ALS) can present with varying degrees of upper
motor neuron (UMN) and lower motor neuron dysfunction. Previous diffusion tensor imaging …

Therapeutic development in amyotrophic lateral sclerosis (ALS) is hampered by the lack of
suitable biomarkers that might be sensitive to spatial and temporal patterns of …

Aims To investigate microstructural impairments of corticospinal tracts (CSTs) with different
origins in amyotrophic lateral sclerosis (ALS) using neurite orientation dispersion and …

Neuroimaging allows investigating the extent of neurological systems degeneration in
amyotrophic lateral sclerosis (ALS). Advanced MRI methods can detect changes related to …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative system disorder
affecting both upper and lower motor neurons. Despite supportive electrophysiological …

BACKGROUND AND PURPOSE: ALS leads to macrostructural (ie, cortical atrophy and
hyperintensities along the corticospinal tract) and microstructural (ie, gray matter intrinsic …

Background and purpose Amyotrophic lateral sclerosis (ALS) is a progressive
neurodegenerative disorder characterized by the loss of both upper and lower motor …