BACKGROUND AND PURPOSE: Most DTI studies in ALS have been limited to the
assessment of the CST damage. In this study, we used DTI tractography to investigate …

Objectives To explore the sensitivity of potential DTI-based biomarkers in detecting
microstructural changes for whole-brain white matter in early stage amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease that
causes progressive degeneration of motor neurons in the brain and the spinal cord …

Objective The corticospinal tract (CST) reveals progressive microstructural alterations in ALS
measurable by DTI. The aim of this study was to evaluate fractional anisotropy (FA) along …

Studies involving diffusion tensor imaging (DTI) of amyotrophic lateral sclerosis (ALS) with
whole-brain voxel-based analysis yielded variable findings. A systematic review was …

BACKGROUND: Clinical identification of upper motor neuron (UMN) dysfunction in
amyotrophic lateral sclerosis (ALS) is often difficult, particularly early in the course of the …

OBJECTIVE: Aim of present study was to evaluate changes in diffusion tensor imaging (DTI)
parameters in the whole brain of 28 patients with amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) is an incurable and progressively fatal
neurodegenerative disease that manifests with distinct clinical phenotypes, which are seen …

Previous neuroimaging studies have revealed that both gray matter (GM) and white matter
(WM) are altered in several morphological aspects in amyotrophic lateral sclerosis (ALS) …

Neurodegenerative process in amyotrophic lateral sclerosis (ALS) has been proven to
involve several cortical and subcortical brain regions within and beyond motor areas …