[HTML][HTML] Temporal and spatial progression of microstructural cerebral degeneration in ALS: A multicentre longitudinal diffusion tensor imaging study

HP Müller, A Abrahao, C Beaulieu, M Benatar… - NeuroImage: Clinical, 2024 - Elsevier
Objective The corticospinal tract (CST) reveals progressive microstructural alterations in ALS
measurable by DTI. The aim of this study was to evaluate fractional anisotropy (FA) along …

Corticospinal tract degeneration in ALS unmasked in T1‐weighted images using texture analysis

A Ishaque, D Mah, P Seres, C Luk… - Human Brain …, 2019 - Wiley Online Library
The purpose of this study was to investigate whether textures computed from T1‐weighted
(T1W) images of the corticospinal tract (CST) in amyotrophic lateral sclerosis (ALS) are …

Assessing neuraxial microstructural changes in a transgenic mouse model of early stage amyotrophic lateral sclerosis by ultra‐high field MRI and diffusion tensor …

RG Gatto, C Weissmann, M Amin… - Animal Models and …, 2020 - Wiley Online Library
Objective Cell structural changes are one of the main features observed during the
development of amyotrophic lateral sclerosis (ALS). In this work, we propose the use of …

Quantitative tractography and tract shape modeling in amyotrophic lateral sclerosis

ME Bastin, LD Pettit, TH Bak… - Journal of Magnetic …, 2013 - Wiley Online Library
Purpose To investigate brain‐wide white matter structural changes associated with
amyotrophic lateral sclerosis (ALS) using an automatic single seed point tractography …

[HTML][HTML] Longitudinal evaluation of cerebral and spinal cord damage in amyotrophic lateral sclerosis

M de Albuquerque, LMT Branco, TJR Rezende… - NeuroImage: Clinical, 2017 - Elsevier
Objective To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral
Sclerosis (ALS) progression. Methods Twenty-seven patients and 27 controls performed two …

Region‐specific impairment of the cervical spinal cord (SC) in amyotrophic lateral sclerosis: a preliminary study using SC templates and quantitative MRI (diffusion …

H Rasoanandrianina, AM Grapperon… - NMR in …, 2017 - Wiley Online Library
In this preliminary study, our objective was to investigate the potential of high‐resolution
anatomical imaging, diffusion tensor imaging (DTI) and conventional/inhomogeneous …

A distinct MR imaging phenotype in amyotrophic lateral sclerosis: correlation between T1 magnetization transfer contrast hyperintensity along the corticospinal tract …

G Carrara, C Carapelli, F Venturi… - American journal …, 2012 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: In the search for a diagnostic marker in ALS, we focused
our attention on the hyperintense signal intensity in T1 MTC MR images along the CST …

Diffusion tensor MRI changes in gray structures of the frontal-subcortical circuits in amyotrophic lateral sclerosis

G Barbagallo, G Nicoletti, A Cherubini, M Trotta… - Neurological …, 2014 - Springer
In this study, we used an automated segmentation of regions of interest and co-registration
to diffusion tensor imaging (DTI) images to investigate whether microstructural abnormalities …

Central white matter degeneration in bulbar-and limb-onset amyotrophic lateral sclerosis

A Cardenas-Blanco, J Machts, J Acosta-Cabronero… - Journal of …, 2014 - Springer
Previous studies using diffusion tensor imaging (DTI) have examined for differences
between bulbar-and limb-onset amyotrophic lateral sclerosis (ALS). Findings between …

Direct evidence of intra-and interhemispheric corticomotor network degeneration in amyotrophic lateral sclerosis: an automated MRI structural connectivity study

S Rose, K Pannek, C Bell, F Baumann, N Hutchinson… - Neuroimage, 2012 - Elsevier
Although the pathogenesis of amyotrophic lateral sclerosis (ALS) is uncertain, there is
mounting neuroimaging evidence to suggest a mechanism involving the degeneration of …