Previous studies using diffusion tensor imaging (DTI) have examined for differences
between bulbar-and limb-onset amyotrophic lateral sclerosis (ALS). Findings between …

We prospectively investigated pathological modifications in the corticospinal tract (CST), by
diffusion tensor imaging (DTI) in 14 patients with sporadic amyotrophic lateral sclerosis …

Objective To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral
Sclerosis (ALS) progression. Methods Twenty-seven patients and 27 controls performed two …

In this study, we used an automated segmentation of regions of interest and co-registration
to diffusion tensor imaging (DTI) images to investigate whether microstructural abnormalities …

Background Corticospinal tract (CST) degeneration and cortical atrophy are consistent
features of amyotrophic lateral sclerosis (ALS). We hypothesised that neurite orientation …

Background Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically
heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid …

Background Brainstem pathology is a hallmark feature of ALS, yet most imaging studies
focus on cortical grey matter alterations and internal capsule white matter pathology …

In amyotrophic lateral sclerosis (ALS), diffusion weighted magnetic resonance imaging (DW-
MRI) has produced mounting evidence of a widespread white matter (WM) damage within …

The aim of this study was to investigate the extent of cortical and subcortical lesions in
amyotrophic lateral sclerosis (ALS) using, in combination, voxel based diffusion tensor …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by the loss of both upper and lower motor neurons. Studies using metrics …