ABSTRACT BACKGROUND AND PURPOSE We attempted to measure DTI parameters of
the brainstem pyramidal tract using two approaches, ie, simple ROI and tract‐specific …

The diagnosis of amyotrophic lateral sclerosis (ALS) remains a clinical diagnosis. It is based
on the combination of both upper and lower motor neuron signs in the neurologic …

Objective Damage to the cerebral tissue structural connectivity associated with amyotrophic
lateral sclerosis (ALS), which extends beyond the motor pathways, can be visualised by …

Background and aims Considering the great heterogeneity of amyotrophic lateral sclerosis
(ALS), the identification of accurate prognostic predictors is fundamental for both the clinical …

Objective Diffusion tensor imaging (DTI) is sensitive to white matter tract pathology. A core
signature involving the corticospinal tracts (CST s) has been identified in amyotrophic lateral …

Primary lateral sclerosis (PLS) is a motor neuron disease characterized by spinobulbar
spasticity, absence of progressive lower motor neuron (LMN) dysfunction and marked by a …

Aims To evaluate microstructural impairment in the thalamus and thalamocortical
connectivity using neurite orientation dispersion and density imaging (NODDI) in …

Purpose Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain
degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical …

Diffusion tensor imaging (DTI) allows the in vivo imaging of pathological white matter
alterations, either with unbiased voxel-wise or hypothesis-guided tract-based analysis …

Extensive pathological evidence indicates that axonal degeneration represents an early and
critical event in amyotrophic lateral sclerosis (ALS). Unfortunately, few MRI studies have …