Pharmacology of morphine metabolites
PK Janicki - Current Pain and Headache Reports, 1997 - Springer
Morphine is metabolized into several metabolites, most of them having some pharmacologic
activity. The major metabolic pathway of morphine includes formation of glucuronides of …
activity. The major metabolic pathway of morphine includes formation of glucuronides of …
[HTML][HTML] Relationships among morphine metabolism, pain and side effects during long-term treatment: an update
G Andersen, L Christrup, P Sjøgren - Journal of pain and symptom …, 2003 - Elsevier
The two metabolites of morphine, morphine-3-glucuronide (M3G) and morphine-6-
glucuronide (M6G), have been studied intensively in animals and humans during the past …
glucuronide (M6G), have been studied intensively in animals and humans during the past …
[HTML][HTML] Opioid metabolites
J Lötsch - Journal of pain and symptom management, 2005 - Elsevier
The metabolism of opioids closely relates to their chemical structure. Opioids are subject to
O-dealkylation, N-dealkylation, ketoreduction, or deacetylation leading to phase-I …
O-dealkylation, N-dealkylation, ketoreduction, or deacetylation leading to phase-I …
The metabolite morphine‐6‐glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function
RK Portenoy, HT Thaler, CE Inturrisi… - Clinical …, 1992 - Wiley Online Library
Morphine‐6‐glucuronide is a metabolite of morphine that binds to the opioid receptor and is
analgesic in animals and humans. Although accumulation of morphine‐6‐glucuronide in …
analgesic in animals and humans. Although accumulation of morphine‐6‐glucuronide in …
Is morphine-3-glucuronide of therapeutic relevance?
C Skarke, G Geisslinger, J Lötsch - Pain, 2005 - journals.lww.com
When patients present with neuroexcitatory effects or hyperalgesia/allodynia during
morphine therapy, the main metabolite of morphine, morphine-3-glucuronide (M3G), has …
morphine therapy, the main metabolite of morphine, morphine-3-glucuronide (M3G), has …
Disposition of morphine and its glucuronide metabolites after oral and rectal administration: evidence of route specificity
N Babul, AC Darke - Clinical Pharmacology & Therapeutics, 1993 - Wiley Online Library
Morphine‐6‐glucuronide is a metabolite of morphine that shows significant analgesic effects
in animals and humans. To evaluate route‐specific differences in the potential contribution …
in animals and humans. To evaluate route‐specific differences in the potential contribution …
Morphine-6-glucuronide: morphine's successor for postoperative pain relief?
ELA van Dorp, R Romberg, E Sarton… - Anesthesia & …, 2006 - journals.lww.com
In searching for an analgesic with fewer side effects than morphine, examination of
morphine's active metabolite, morphine-6-glucuronide (M6G), suggests that M6G is possibly …
morphine's active metabolite, morphine-6-glucuronide (M6G), suggests that M6G is possibly …
Role of morphine's metabolites in analgesia: concepts and controversies
E Wittwer, SE Kern - The AAPS journal, 2006 - Springer
The metabolites of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide
(M3G), have been extensively studied for their contribution to clinical effects following …
(M3G), have been extensively studied for their contribution to clinical effects following …
Morphine metabolism--pharmacokinetics and pharmacodynamics
G Andersen, LL Christrup, P Sjøgren - Ugeskrift for Laeger, 1997 - europepmc.org
With the increasing use of morphine, growing interest for the clinical implications of its
metabolites, morphine-3-glucuronide (M-3-G) and morphine-6-glucuronide (M-6-G) has …
metabolites, morphine-3-glucuronide (M-3-G) and morphine-6-glucuronide (M-6-G) has …
In search of a role for the morphine metabolite morphine-3-glucuronide
CW Vaughan, M Connor - Anesthesia & Analgesia, 2003 - journals.lww.com
Morphine is the most commonly used opioid an-algesic, and while extremely effective in
relieving moderate to severe acute pain, it produces a number of well-characterized …
relieving moderate to severe acute pain, it produces a number of well-characterized …