Morphine is metabolized into several metabolites, most of them having some pharmacologic
activity. The major metabolic pathway of morphine includes formation of glucuronides of …

The two metabolites of morphine, morphine-3-glucuronide (M3G) and morphine-6-
glucuronide (M6G), have been studied intensively in animals and humans during the past …

The metabolism of opioids closely relates to their chemical structure. Opioids are subject to
O-dealkylation, N-dealkylation, ketoreduction, or deacetylation leading to phase-I …

Morphine‐6‐glucuronide is a metabolite of morphine that binds to the opioid receptor and is
analgesic in animals and humans. Although accumulation of morphine‐6‐glucuronide in …

When patients present with neuroexcitatory effects or hyperalgesia/allodynia during
morphine therapy, the main metabolite of morphine, morphine-3-glucuronide (M3G), has …

Morphine‐6‐glucuronide is a metabolite of morphine that shows significant analgesic effects
in animals and humans. To evaluate route‐specific differences in the potential contribution …

In searching for an analgesic with fewer side effects than morphine, examination of
morphine's active metabolite, morphine-6-glucuronide (M6G), suggests that M6G is possibly …

The metabolites of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide
(M3G), have been extensively studied for their contribution to clinical effects following …

With the increasing use of morphine, growing interest for the clinical implications of its
metabolites, morphine-3-glucuronide (M-3-G) and morphine-6-glucuronide (M-6-G) has …

Morphine is the most commonly used opioid an-algesic, and while extremely effective in
relieving moderate to severe acute pain, it produces a number of well-characterized …