This brief review will emphasize four interconnected pathways that can lead to functional
abnormalities of surfactant that contribute to lung mechanics and gas exchange …

Objective: It has been demonstrated that pulmonary surfactant plays a role in the
pathophysiology of ventilation-induced lung injury (VILI). Therefore, we investigated whether …

In an attempt to restore functional surfactant to the lungs of patients with the adult respiratory
distress syndrome (ARDS), we have treated six patients within the first 2 days of the onset of …

Lung surfactant is crucial for optimal pulmonary function throughout life. An absence or
deficiency of surfactant can affect the surfactant pool leading to respiratory distress. Even if …

Integrating basic and clinical research on the biophysical and physiological functions of
pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on …

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a life-threatening form of
respiratory failure that affects a heterogeneous population of critically ill patients. Although …

Inactivation of pulmonary surfactant may be important in acute lung injury and acute
respiratory distress syndrome. Treatment of surfactant dysfunction by instilling exogenous …

Objectives Sepsis is one of the most important predisposing factors for the development of
the acute respiratory distress syndrome (ARDS). Alterations of pulmonary surfactant …

Pulmonary surfactant is a highly surface-active material that lines the alveolar surface of the
lung. The major function of pulmonary surfactant is the reduction of surface tension at the air …

Acute respiratory distress syndrome (ARDS) continues to be a major cause of morbidity and
mortality in critically ill patients. In this issue of the Journal, Anzueto et al. 1 report the results …