Objective To assess the performance of a combination of three quantitative MRI markers
(iron deposition, basal neuronal metabolism, and regional atrophy) for differential diagnosis …

Our objective was to assess and compare the diagnostic sensitivity of conventional MRI
(cMRI), magnetization transfer imaging (MTI), diffusion-weighted imaging (DWI), and proton …

Objectives To explore whether the combined analysis of motor and bulbar region of M1 on
susceptibility-weighted imaging (SWI) can be a valid biomarker for amyotrophic lateral …

Purpose To investigate the whole-brain landscape of iron-related abnormalities in
amyotrophic lateral sclerosis (ALS) by using the in vivo MRI technique of quantitative …

Objective To construct a clinical diagnostic biomarker using state-of-the-art microstructural
MRI in the motor cortex of people with amyotrophic lateral sclerosis (ALS). Methods Clinical …

Objective Reliable biomarkers for amyotrophic lateral sclerosis (ALS) are needed, given the
clinical heterogeneity of the disease. Here, we provide proof‐of‐concept for using …

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects upper
and lower motor neurons. Observational and intervention studies can be tracked using …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by cortical and spinal motor neuron dysfunction. Routine magnetic resonance …

It is agreed that conventional magnetic resonance imaging (MRI) of the brain and spine is
one of the core elements in the differential diagnostic work up of patients with clinical signs …

Background Dysregulation of iron in the cerebral motor areas has been hypothesized to
occur in individuals with amyotrophic lateral sclerosis (ALS). There is still limited knowledge …