[HTML][HTML] Glial cells—The strategic targets in amyotrophic lateral sclerosis treatment
T Filipi, Z Hermanova, J Tureckova, O Vanatko… - Journal of clinical …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease, which is characterized by
the degeneration of motor neurons in the motor cortex and the spinal cord and subsequently …
the degeneration of motor neurons in the motor cortex and the spinal cord and subsequently …
Modelling amyotrophic lateral sclerosis: progress and possibilities
P Van Damme, W Robberecht… - Disease models & …, 2017 - journals.biologists.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects the
motor system and presents with progressive muscle weakness. Most patients survive for …
motor system and presents with progressive muscle weakness. Most patients survive for …
Spinal inhibitory neurons degenerate before motor neurons and excitatory neurons in a mouse model of ALS
R Montañana-Rosell, R Selvan… - Science …, 2024 - science.org
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of somatic motor
neurons. A major focus has been directed to motor neuron intrinsic properties as a cause for …
neurons. A major focus has been directed to motor neuron intrinsic properties as a cause for …
[HTML][HTML] Amyotrophic lateral sclerosis: recent genetic highlights
MA White, J Sreedharan - Current opinion in neurology, 2016 - journals.lww.com
Striking advances in our understanding of the genetic heterogeneity of ALS continue to be
made, year on year. These implicate proteostasis, RNA export, nuclear transport, the …
made, year on year. These implicate proteostasis, RNA export, nuclear transport, the …
The 'omics' of amyotrophic lateral sclerosis
D Caballero-Hernandez, MG Toscano… - Trends in molecular …, 2016 - cell.com
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease that primarily
affects motor neurons and is accompanied by sustained unregulated immune responses …
affects motor neurons and is accompanied by sustained unregulated immune responses …
ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration
JM Ravits, AR La Spada - Neurology, 2009 - AAN Enterprises
Heterogeneity of motor phenotypes is a clinically well-recognized fundamental aspect of
amyotrophic lateral sclerosis (ALS) and is determined by variability of 3 independent primary …
amyotrophic lateral sclerosis (ALS) and is determined by variability of 3 independent primary …
Glia cells in amyotrophic lateral sclerosis: new clues to understanding an old disease?
C Neusch, M Bähr… - Muscle & Nerve: Official …, 2007 - Wiley Online Library
In classic neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), the
pathogenic concept of a cell‐autonomous disease of motor neurons has been challenged …
pathogenic concept of a cell‐autonomous disease of motor neurons has been challenged …
Understanding ALS: new therapeutic approaches
A Musarò - The FEBS journal, 2013 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with
motor neuron degeneration, muscle atrophy and paralysis. Although numerous pathological …
motor neuron degeneration, muscle atrophy and paralysis. Although numerous pathological …
[HTML][HTML] A systematic review of genotype–phenotype correlation across cohorts having causal mutations of different genes in ALS
O Connolly, L Le Gall, G McCluskey… - Journal of Personalized …, 2020 - mdpi.com
Amyotrophic lateral sclerosis is a rare and fatal neurodegenerative disease characterised by
progressive deterioration of upper and lower motor neurons that eventually culminates in …
progressive deterioration of upper and lower motor neurons that eventually culminates in …
[HTML][HTML] Current insights in the molecular genetic pathogenesis of amyotrophic lateral sclerosis
W Zhou, R Xu - Frontiers in Neuroscience, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease
that leads to the massive loss of motor neurons in cerebrum, brain stem and spinal cord. It …
that leads to the massive loss of motor neurons in cerebrum, brain stem and spinal cord. It …