Abstract Morphine (1–100 μm) was found to inhibit several concomitant events in brain
slices and synaptosomes which are augmented by depolarizing agents. Thus, 45 Ca 2+ …

The requirement for calcium in membrane stabilization and the functioning of neuronal
systems is well established [1, 2], particularly in excitation coupling m~ h~ isms [3, 4] and in …

It was confirmed that morphine administration in vivo produced a selective decrease in the
calcium content of synaptosomal fractions prepared from rat cerebral cortices. This effect …

Narcotic analgesics effectively inhibit the binding of Ca 2+ to phospholipids in vitro.
Morphine and nalorphine also inhibit the Ca 2+ transported by phospholipids obtained from …

The effect of morphine on the uptake of 45Ca++ was studied in lysed synaptosomes
obtained from homogenates of whole mouse brain. The addition of morphine, 10 (-6) M, to …

Acute subcutaneous injection of 25 mg/kg of morphine in rats decreased synaptosomal
CA++ levels by 29% without altering the Ca++ content of other subcellular fractions. In …

The in vivo administration of a single dose of morphine produces a decrease of tissue
calcium in the rat brain. This decrease is observed to be linear, dose‐dependent, time …

Abstract Morphine (1 and 5 mg/kg), administered intravenously, increased the rate of efflux
of purines from intact rat cerebral cortises prelabelled with 3 H-adenosine. Naloxone …

Effects of morphine on calcium uptake into synaptosomes isolated from acutely or
chronically morphine-tolerant rat brain was studied. Addition of morphine inhibited the …

Synaptosomes were prepared from morphine-tolerant and non-tolerant mice. Significantly
higher levels of basal free intracellular calcium were observed in the synaptosomes from the …