The pharmacokinetics of the synthetic narcotic agent LAAM, its pharmacologically active,
demethylated metabolites NORLAAM and DINORLAAM, and also the dextro‐enantiomer …

The metabolism and disposition of the long-acting narcotic analygesic l-alpha-
acetylmethadol (LAAM) were studied in the rat. 3H-LAAM was administered to male and …

Because of its properties of effective suppression of opiate withdrawal symptoms and longer
duration of action,(-)-a-acetylmethadol (LAAM), a synthetic congener of methadone has …

l‐α‐Acetylmethadol (LAAM) was administered orally to two groups of subjects; one group
received methadone. 50 mg/day. for three months previously and the other group were …

LAAM) is a synthetic congener [1, 21 of methadone. The presence of two asymmetric carbon
atoms in the molecule gives rise to two diastereoisomeric pairs [3] a and 0, of which the a …

Pharmacodynamic profiles of 1-alpha-acetylmethadol (LAAM) and its N-demethylated
metabolites, nor-LAAM and dinor-LAAM, during self-administration in the dependent rat.

The disposition of 1-α-acetylmethadol (LAAM) in plasma and urine was monitored by
GC/CIMS following oral administration of 10 doses (0.73–1.5 mg/kg) over 42 days, to twelve …

A gas chromatographic method is reported for simultaneously determining acetyl‐methadol,
noracetylmethadol, and dinoracetylmethadol in plasma. Minimum detectable concentrations …

MATERIALS AND METHODS The radiochemical purity of 1-~ 7-(2-~ H) acetylmethadol (3H)-
LAAM (sp. act. 40 mCi/mmol) was confirmed by tlc and radioscanning of chromatograms …

Chronic dosing of nor-LAAM produced highly significant in-creases in apparent volume of
distribution(3.03 in acute, 8.62 liters/kg in chronic), total body clearance(7.1 6 in acute, 21.95 …