Favipiravir in patients with early mild-to-moderate coronavirus disease 2019 (COVID-19): a randomized controlled trial

Y Golan, JAS Campos, R Woolson… - Clinical Infectious …, 2023 - academic.oup.com
Background Despite vaccination, many remain vulnerable to coronavirus disease 2019
(COVID-19) and its complications. Oral antivirals to prevent COVID-19 progression are vital …

Favipiravir for treatment of outpatients with asymptomatic or uncomplicated coronavirus disease 2019: a double-blind, randomized, placebo-controlled, phase 2 trial

M Holubar, A Subramanian, N Purington… - Clinical Infectious …, 2022 - academic.oup.com
Background Favipiravir, an oral, RNA-dependent RNA polymerase inhibitor, has in vitro
activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite …

[HTML][HTML] Efficacy of favipiravir in adults with mild COVID-19: a randomized, double-blind, multicentre, placebo-controlled clinical trial

M Bosaeed, A Alharbi, E Mahmoud, S Alrehily… - Clinical Microbiology …, 2022 - Elsevier
Objective To evaluate whether favipiravir reduces the time to viral clearance as documented
by negative RT-PCR results for severe acute respiratory syndrome coronavirus 2 in mild …

[HTML][HTML] Favipiravir for the treatment of patients with COVID-19: a systematic review and meta-analysis

T Manabe, D Kambayashi, H Akatsu, K Kudo - BMC infectious diseases, 2021 - Springer
Background Favipiravir possesses high utility for treating patients with COVID-19. However,
research examining the efficacy and safety of favipiravir for patients with COVID-19 is …

[HTML][HTML] Favipiravir in early symptomatic COVID-19, a randomised placebo-controlled trial

JH McMahon, JSY Lau, A Coldham, J Roney… - …, 2022 - thelancet.com
Background Well tolerated antivirals administered early in the course of COVID-19 infection
when the viremia is highest could prevent progression to severe disease. Favipiravir inhibits …

[HTML][HTML] Real-world effectiveness and optimal dosage of favipiravir for treatment of COVID-19: results from a multicenter observational study in Thailand

P Rattanaumpawan, S Jirajariyavej, K Lerdlamyong… - Antibiotics, 2022 - mdpi.com
Favipiravir is a broad-spectrum oral antiviral agent that shows in vitro activity against SARS-
CoV-2. Presently, data on the real-world effectiveness and optimal dosage of favipiravir for …

[HTML][HTML] Phase 3 trial of coronavir (favipiravir) in patients with mild to moderate COVID-19

TA Ruzhentsova, RA Oseshnyuk… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Favipiravir has demonstrated efficacy against the SARS-CoV-2 virus in several preliminary
studies. This study aimed to evaluate the efficacy and safety of favipiravir for treatment of …

[HTML][HTML] Favipiravir in patients hospitalised with COVID-19 (PIONEER trial): a multicentre, open-label, phase 3, randomised controlled trial of early intervention versus …

PL Shah, CM Orton, B Grinsztejn… - The Lancet …, 2023 - thelancet.com
Background COVID-19 has overwhelmed health services globally. Oral antiviral therapies
are licensed worldwide, but indications and efficacy rates vary. We aimed to evaluate the …

Early treatment of Favipiravir in COVID-19 patients without pneumonia: a multicentre, open-labelled, randomized control study

R Sirijatuphat, W Manosuthi… - Emerging Microbes & …, 2022 - Taylor & Francis
We investigated Favipiravir (FPV) efficacy in mild cases of COVID-19 without pneumonia
and its effects towards viral clearance, clinical condition, and risk of COVID-19 pneumonia …

[HTML][HTML] Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2× 2 factorial placebo-controlled trial of early antiviral therapy in …

DM Lowe, LAK Brown, K Chowdhury, S Davey… - PLoS …, 2022 - journals.plos.org
Background Early antiviral treatment is effective for Coronavirus Disease 2019 (COVID-19)
but currently available agents are expensive. Favipiravir is routinely used in many countries …