Mechanisms and clinical consequences of acute lung injury

V Fanelli, VM Ranieri - Annals of the American Thoracic Society, 2015 - atsjournals.org
Acute respiratory distress syndrome (ARDS) was first described in 1967, and since then
there have been a large number of studies addressing its pathogenesis and therapies …

[HTML][HTML] Clinical review: Exogenous surfactant therapy for acute lung injury/acute respiratory distress syndrome-where do we go from here?

A Dushianthan, R Cusack, V Goss, AD Postle… - Critical Care, 2012 - Springer
Acute lung injury and acute respiratory distress syndrome (ARDS) are characterised by
severe hypoxemic respiratory failure and poor lung compliance. Despite advances in clinical …

[HTML][HTML] Pharmacologic treatments for acute respiratory distress syndrome and acute lung injury: systematic review and meta-analysis

N Adhikari, KEA Burns, MO Meade - Treatments in respiratory medicine, 2004 - Springer
Background: Multiple pharmacologic treatments have been studied for patients with acute
respiratory distress syndrome (ARDS) and acute lung injury (ALI). Our objective was to …

The future of surfactant therapy during ALI/ARDS

JF Lewis, RAW Veldhuizen - Seminars in respiratory and …, 2006 - thieme-connect.com
The importance of pulmonary surfactant in maintaining normal lung function, and the
observations that alterations in endogenous surfactant contribute to the lung dysfunction …

Pharmacologic treatments for acute respiratory distress syndrome

N Qadir, SY Chang - Critical care clinics, 2021 - criticalcare.theclinics.com
Over 50 years have passed since the acute respiratory distress syndrome (ARDS) was first
described. 1 Despite the passage of more than one-half of a century, almost all of ARDS …

Acute lung injury and the acute respiratory distress syndrome: challenges in clinical trial design

TW Rice, GR Bernard - Clinics in chest medicine, 2006 - chestmed.theclinics.com
Previously thought to be an uncommon disease, a recent epidemiologic study found the
incidence of acute lung injury (ALI) in the United States to be almost 1 per 1000 person …

Exogenous surfactant therapy for ARDS

A Maruscak, JF Lewis - Expert Opinion on Investigational Drugs, 2006 - Taylor & Francis
Regardless of the cause, a common pathophysiological feature of patients with acute
respiratory distress syndrome is a dysfunction of the endogenous surfactant system …

Emerging drugs for treating the acute respiratory distress syndrome

TD Shaw, DF McAuley, CM O'Kane - Expert opinion on emerging …, 2019 - Taylor & Francis
Introduction: The acute respiratory distress syndrome (ARDS) is a common and catastrophic
condition, with a high mortality rate and economic burden on society. Despite 50 years of …

Acute respiratory distress syndrome and multiple organ failure

L Del Sorbo, AS Slutsky - Current opinion in critical care, 2011 - journals.lww.com
ARDS is a severe lung disease characterized by a very complex pathophysiology, involving
not only the respiratory system but also nonpulmonary distal organs. Elucidation of the …

Why do patients who have acute lung injury/acute respiratory distress syndrome die from multiple organ dysfunction syndrome? Implications for management

JL Vincent, M Zambon - Clinics in chest medicine, 2006 - chestmed.theclinics.com
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are a complex
response of the lung to direct or indirect insults, characterized by sudden-onset severe …