The aim of this study was to characterize the reversible cerebral uptake of morphine in the
pig by measuring the changing arterio-venous plasma concentration gradient over the brain …

Intracerebral microdialysis was utilised to obtain information regarding how morphine is
transported across the blood–brain barrier (BBB). In a patient with a severe brain injury, we …

Background and purpose: The effect of age on the distribution of morphine and morphine‐3‐
glucuronide (M3G) across the blood–brain barrier (BBB) was studied in a sheep model …

Purpose. The objective of this study was to investigate the possible influence of probenecid
on morphine transport across the blood-brain barrier (BBB) in rats. Methods. Microdialysis …

The unbound concentration of morphine in striatum of rats was estimated during a constant
rate infusion of morphine 14 μmol/h∗ kg, by use of the microdialysis technique and …

Regional morphine accumulation was examined in 8 brain areas (cerebral cortex,
hippocampus, striatum, midbrain, hypothalamus, thalamus, medulla oblongata and …

Aims In experimental studies, morphine pharmacokinetics is different in the brain compared
with other tissues due to the properties of the blood–brain barrier, including action of efflux …

Morphine has been predicted to show nonlinear blood-brain barrier transport at lower
concentrations. In this study, we investigated the possibility of separating active influx of …

Microdialysis was used to sample morphine 6-glucuronide (M6G) and morphine in striatal
extracellular fluid after systemic administration in awake, freely moving rats. Morphine or …

Background and purpose: At present there are few data regarding the rate and extent of
brain–blood partitioning of the opioid active metabolite of morphine, morphine‐6 …