Morphine: new aspects in the study of an ancient compound
S Benyhe - Life sciences, 1994 - Elsevier
Morphine is the most widely used compound among narcotic analgesics and remains the
gold standard when the effects of other analgetic drugs are compared. Apart from its …
gold standard when the effects of other analgetic drugs are compared. Apart from its …
The disposition of morphine and its 3-and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of …
RW Milne, RL Nation, AA Somogyi - Drug metabolism reviews, 1996 - Taylor & Francis
The purposes of this comprehensive review are: first. to introduce the reader to the historical
and current uses for morphine and to give a brief outline of the relevant physicochemical …
and current uses for morphine and to give a brief outline of the relevant physicochemical …
Endogenous morphine and its metabolites in mammals: history, synthesis, localization and perspectives
A Laux-Biehlmann, J Mouheiche, J Veriepe, Y Goumon - Neuroscience, 2013 - Elsevier
Morphine derived from Papaver somniferum is commonly used as an analgesic compound
for pain relief. It is now accepted that endogenous morphine, structurally identical to vegetal …
for pain relief. It is now accepted that endogenous morphine, structurally identical to vegetal …
Biological disposition of morphine and its surrogates
EL Way, TK Adler - Bulletin of the World Health Organization, 1962 - ncbi.nlm.nih.gov
Le sort de la morphine et de ses succedanes synth6tiques dans l'organisme humain et
animal, la connaissance du groupe chimique qui exerce une action hautement selective sur …
animal, la connaissance du groupe chimique qui exerce une action hautement selective sur …
Morphine 6-glucuronide: a metabolite of morphine with greater emetic potency than morphine in the ferret.
PI Thompson, S Bingham, PL Andrews… - British journal of …, 1992 - ncbi.nlm.nih.gov
The emetic potencies of morphine and its metabolite morphine 6-glucuronide have been
determined in the ferret by constructing dose-response curves for mean total retches and …
determined in the ferret by constructing dose-response curves for mean total retches and …
Isolation and identification of morphine N-oxide α-and β-dihydromorphines, β-or γ-isomorphine, and hydroxylated morphine as morphine metabolites in several …
SY Yeh, HA Krebs, CW Gorodetzky - Journal of Pharmaceutical Sciences, 1979 - Elsevier
New morphine metabolites in the urine of guinea pigs, rats, rabbits, cats, monkeys, and
humans were isolated with column chromatography, solvent extraction, and TLC and …
humans were isolated with column chromatography, solvent extraction, and TLC and …
Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.
D Paul, KM Standifer, CE Inturrisi… - Journal of Pharmacology …, 1989 - ASPET
Morphine-6 beta-glucuronide is a major metabolite of morphine with potent analgesic
actions. To define more fully the importance of this compound in morphine action, we have …
actions. To define more fully the importance of this compound in morphine action, we have …
[HTML][HTML] The pharmacological basis of opioids
C Ghelardini, LDC Mannelli… - Clinical Cases in Mineral …, 2015 - ncbi.nlm.nih.gov
An opioid is a chemical that binds to opioid receptors, which are widely distributed in the
central and peripheral nervous system and gastrointestinal tract. The different effects elicited …
central and peripheral nervous system and gastrointestinal tract. The different effects elicited …
Biochemical basis for analgesic activity of morphine-6-glucuronide—I: Penetration of morphine-6-glucuronide in the brain of rats
H Yoshimura, S Îda, K Oguri, H Tsukamoto - Biochemical pharmacology, 1973 - Elsevier
To understand the potent analgesic action of morphine-6-glucuronide (M-6-G), which was
reported previously to be a minor metabolite of morphine in several mammalian species, the …
reported previously to be a minor metabolite of morphine in several mammalian species, the …
Role of morphine's metabolites in analgesia: concepts and controversies
E Wittwer, SE Kern - The AAPS journal, 2006 - Springer
The metabolites of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide
(M3G), have been extensively studied for their contribution to clinical effects following …
(M3G), have been extensively studied for their contribution to clinical effects following …
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