Concentrations of morphine and its 3-and 6-glucuronide metabolites (M3G and M6G) in
plasma, brain, and urine of rats exposed to morphine for either 24 or 48 h were measured …

1. The O-dealkylation of 3-O-tert.-butylmorphine, a new derivative of morphine, has been
compared to the O-dealkylation of codeine by the rat. Rats were given either 3-O-tert …

Background Morphine, the major alkaloid of opium of Papaver somniferum, is one of the
strongest analgesic compounds known." Endogenous morphine" has been long isolated …

Chronic morphine administration to adult male rats has long been known to lower hepatic
cytochrome P-450 content and its dependent mixed function oxidase activity. More recently …

Adult homozygous Gunn and Wistar rats were given daily injections with subcutaneous
doses of morphine sulfate starting at 20 mg/kg and gradually increasing to 35 mg/kg over a …

Morphinone, a toxic metabolite, was formed from morphine by NAD (P)-dependent morphine
6-dehydrogenase (s) in both the cytosol and microsomal fractions of the rabbit liver at pH …

The distribution of free and" bound" morphine in dogs and rats is selective for certain tissues
and fluids." Bound" morphine is found in gall bladder bile in concentrations many fold …

Evidence has been presented for the formation in vivo in the rat of a new urinary metabolite
of morphine, to which 2, 3-dihydrodiol structure has been tentatively assigned. In vitro, rat …

The interaction of morphine with an enzymatic oxidation-reduction system was investigated.
It has been reported that morphine is converted to a highly water-soluble metabolite by …

Evidence for the specificity of the radioimmunoassay for morphine in plasma was provided
by demonstrating similar results with a fluorometric assay method which did not measure …