In this preliminary study, our objective was to investigate the potential of high‐resolution
anatomical imaging, diffusion tensor imaging (DTI) and conventional/inhomogeneous …

Objective To evaluate multimodal MRI of the spinal cord in predicting disease progression
and one-year clinical status in amyotrophic lateral sclerosis (ALS) patients. Materials and …

Purpose To study the relative contributions of brain and upper cervical spinal cord
compartmental atrophy to disease aggressiveness in amyotrophic lateral sclerosis (ALS) …

Objective: To define the temporal evolution of intrinsic tissue damage and atrophy in the
cervical cord and the brain portion of the corticospinal tracts (CST) from patients with …

Several quantitative magnetic resonance imaging (MRI) techniques have been proposed to
investigate microstructural tissue changes in amyotrophic lateral sclerosis (ALS) including …

Objective To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral
Sclerosis (ALS) progression. Methods Twenty-seven patients and 27 controls performed two …

Therapeutic development in amyotrophic lateral sclerosis (ALS) is hampered by the lack of
suitable biomarkers that might be sensitive to spatial and temporal patterns of …

The upper cervical spinal cord is measured in a large longitudinal amyotrophic lateral
sclerosis (ALS) cohort to evaluate its role as a biomarker. Specifically, the cervical spinal …

Motor neuron damage and cortical spinal tract (CST) degeneration are pathological features
of amyotrophic lateral sclerosis (ALS). We combined whole-brain diffusion tensor imaging …

Our objective was to investigate spinal cord (SC) atrophy in amyotrophic lateral sclerosis
(ALS) patients, and to determine whether it correlates with clinical parameters. Forty-three …