Opioids forM the cornerstone of the pharmacologic armamentarium for the treatment of pain.
Despite their long history of use, much confusion and misperception still surrounds their use …

METHODS We administered fentanyl intravenously (IV) to healthy unpremedicated patients
while they were breathing 100 percent O2 unassisted, and observed the effects on the …

Fentanyl, a potent lipid-soluble opioid which was first synthesized more than 40 years ago,
is still the most popular opioid used in the perioperative period throughout the world …

The tape recorded EEGs of 127 patients anesthetized with large doses of opioids were
retrospectively analyzed for evidence of opioid-induced seizures, and in particular …

The hemodynamic changes, plasma norepinephrine levels, pupil size, and rapidity of
postoperative mental recovery were measured and compared in 72 patients randomly …

Fentanyl and alfentanil produce very similar electroencephalographic (EEG) changes in
humans. With increasing serum concentrations of either narcotic, progressive slowing in …

Fentanyl, a synthetic opiate with a (clinical) potency of 50 to 100 times that of morphine, was
introduced into clinical practice in the early 1960s. Usually administered by single …

Background Despite a large number of clinical investigations in postoperative patients, the
pharmacology of epidural fentanyl, alfentanil, and sufentanil has not been well characterized …

A comment on this article appears in" Fentanyl and sufentanil anesthesia revisited: establish
an effective plasma concentration and achieve it at the right time." Anesthesiology. 1991 …

Background Opioid-related side effects associated with intravenous patient-controlled
analgesia can be reduced by a low-dose naloxone infusion. The influence of nalmefene, a …