This study evaluated levo‐alpha‐acetylmethadol hydrochloride (LAAM), a long‐acting
morphine‐like (μ) agonist approved in 1993 to treat opiate dependence. Sprague‐Dawley …

This study characterized discriminative stimulus and other effects of naltrexone in rhesus
monkeys treated daily with the long-acting opioid l-alpha acetylmethadol (LAAM). An initial …

This study was conducted to determine the safety and pharmacokinetics of LAAM in male
and female opioid-dependent patients transferred from methadone maintenance treatment …

Rats maintained dependence by the self-administration of LAAM or morphine. Following the
substitution of saline for LAAM, REM sleep was not disrupted, and the frequency of lever …

l‐α‐Acetylmethadol (LAAM) was administered orally to two groups of subjects; one group
received methadone. 50 mg/day. for three months previously and the other group were …

Levomethadyl Acetate (LAAM) for the Treatment of Opioid Dependence: A Multisite, Open-Label
Study of LAAM Safety and an Evaluati Page 1 Levomethadyl Acetate (LAAM) for the …

Abstract I-α-Acetylmethadol (LAAM) is approved as a substitute for methadone for the
treatment of opiate addiction. Analytical methods are needed to quantitate LAAM and its two …

Despite its structural similarity to codeine, tramadol is an unusual analgesic whose
antinociceptive efficacy is not solely a result of opioid actions but also of its apparent …

We investigated the rate of penetration into and the intra‐relationship between the serum,
cerebrospinal fluid (CSF) and regional brain extracellular fluid (bECF) compartments …