Purpose. To develop a viable, single pass rat head perfusion modeluseful for
pharmacokinetic studies. Methods. A viable rat head preparation, perfused with MOPS …

A continuous fentanyl infusion was administered to eight adult, male beagle dogs for a
duration of~ 400 min at a rate of 30 μg/kg/h. The extent of respiratory depression was …

The log BB parameter is the logarithm of the ratio of a compound's equilibrium
concentrations in the brain tissue versus the blood plasma. This parameter is a useful …

The microsomal cytochromes P-450 and b 5 and the enzymes of the hepatic microsomal
electron transport system (HMETS) including NADPH-cytochrome c reductase and NADPH …

The pulmonary uptake of l-alpha-acetylmethadol (LAAM) and its major analgesically active
metabolites, nor-LAAM and dinor-LAAM, was studied during a single pass through the …

Methods Find Exp Clin Pharmacol 2005, 27(8): 539-545 Page 1 Methods Find Exp Clin Pharmacol
2005, 27(8): 539-545 Copyright C 2005 Prous Science CCC: 03790355/2005 DOI: 10 …

The value of intracerebral injections as a means of relating brain structure and function is
dependent on the degree of site specificity of the injection. The purpose of this study was to …

The cerebral pharmacokinetics and pharmacodynamics of midazolam and diazepam were
examined in chronically instrumented sheep via measurements of their arterio-venous …

The time delay between drug plasma concentrations and effect has been modeled most
commonly by the effect compartment approach, assuming first-order monoexponential …

Rats bearing cerebrocortical electrodes for recording the electroencephalogram (EEG) were
rendered tolerant to and physically dependent on morphine and subsequently trained to self …