A novel glutathione-conjugated metabolite of morphine has been isolated from the bile of
guinea pigs given morphine. The metabolite was separated by preparative HPLC on a …

Incubation of tritium-labeled morphine and cold glutathione (GSH) or cold morphine and
tritiated GSH with liver microsomal preparations obtained from phenobarbital-treated rats led …

1. Morphinone, a toxic metabolite, and its glutathione adduct (MO-GSH) were identified in
the bile of rat after subcutaneous injection of morphine (25 mg/kg) by hplc procedures. The …

A New Metabolic Pathway of Morphine: In Vivo and In Vitro Formation of Morphinone and
Morphinone-Glutathione Adduct in Guinea Pi Page 1 VoL 255, No.2 Printed in US.A …

Morphinone, identified in the bile of guinea pigs and rats given morphine, is a reactive
electrophile and has the ability to bind to glutathione (GSH) and tissue macromolecules …

Abstract Treatment of fasted rats with relatively high doses of morphine rapidly results in
depletion of hepatic glutathione (GSH) content and marked elevation of serum transaminase …

Isolated rat hepatocytes metabolized morphine to its glucuronide conjugate, morphinone-
glutathione conjugate, normorphine and morphinone. Addition of morphine to the isolated …

Morphine is a potent analgesic and is widely used in the clinical management of severe
acute and chronic pain; however, its clinical usefulness is limited due to the development of …

In our preliminary study, the urinary excretion of morphinone as a new metabolite of
morphine in guinea pigs has been confirmed by isolations of the metabolite as 8-(2 …

Previous studies have led to the partial structural characterization of a glutathionylmorphine
adduct which was isolated from rat liver microsomal incubations. The formation of this …