Illicitly manufactured fentanyl is driving the current opioid crisis, and various fentanyl
analogs are appearing in recreational drug markets worldwide. To assess the potential …

Fentanyl is a highly potent and clinically widely used narcotic analgesic. The synthesis of its
analogs remains a challenge in the attempt to develop highly selective μ-opioid receptor …

Fentanyl analogs represent an important group of new psychoactive substances and
knowing their efficacy and potency might assist in interpreting observed concentrations. The …

Substituted fentanyls are abused and cause rapid fatal overdose. As their pharmacology is
not well characterized, we examined in vitro pharmacology and structure–activity …

Opioids are widely misused and account for almost half of overdose deaths in the United
States. The cost in terms of lives, health care, and lost productivity is significant and has …

This study determined if fentanyl analgesic efficacy predicts the magnitude of tolerance and
μ-opioid receptor regulation. To estimate efficacy, mice were injected ip with saline or …

The ligand binding modes of a series of fentanyl derivatives are examined using a
combination of conformational analysis and molecular docking to the μ-opioid receptor …

The landscape of new psychoactive substances (NPS) is constantly evolving, with new
compounds entering the illicit drug market at a continuous pace. Of these, opioid NPS form a …

Fentanyl rose to prominence as an alternative analgesic to morphine nearly 50 years ago;
today, fentanyl has re-emerged as a dangerous recreational substance. The increased …

In recent years, synthetic opioids have emerged as a predominant cause of drug-overdose-
related fatalities, causing the “opioid crisis.” To design safer therapeutic agents, we …