Abstract Purpose of Review The purpose of this review is to summarize the current
understanding of opioid pathways in mediating and/or modulating analgesia and adverse …

The present study demonstrates that pretreatment of rat brain membranes with (+)-cis-3-
methylfentanyl {(+)-cis-MF}, followed by extensive washing of the membranes, produces a …

Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an
increasing public health threat in the United States and elsewhere. Fentanyl was initially …

The continuous rise in opioid overdoses in the United States is predominantly driven by very
potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls). Although naloxone …

Morphine and structurally related derivatives are highly effective analgesics, and the
mainstay in the medical management of moderate to severe pain. Pharmacological actions …

The discriminative stimulus effects of several μ-opioid agonists were examined under
conditions of opioid sensitization or tolerance, ie, before and after 1-week SC infusions of …

We synthesized fentanyl analogues that possess key groups common to theopioid peptides
to investigate whether or not these two classes of compounds interact with common subsites …

Profiling of the illicit fentanyl supply is invaluable from surveillance and intelligence
perspectives. An important strategy includes the study of chemical attribution signatures (eg …

Mu-opioid receptor agonists such as fentanyl are effective analgesics, but their clinical use is
limited by untoward effects. Adjunct medications may improve the effectiveness and/or safety …

Roughly half of the drug overdose-related deaths in the United States are related to
synthetic opioids represented by fentanyl which is a potent agonist of mu-opioid receptor …