In September 2019, a group of international neurologists gathered in Gold Coast, Australia,
to deconstruct the diagnostic process for amyotrophic lateral sclerosis (ALS) and to try to …

Amyotrophic lateral sclerosis (ALS) is a progressive degeneration of upper and lower motor
neurons. In the absence of any validated biological marker, the diagnosis of ALS depends …

Publisher Summary Amyotrophic lateral sclerosis (ALS) is a progressive disorder
characterized by the degeneration of motor neurons of the primary motor cortex, brainstem …

Objectives Primary lateral sclerosis (PLS) is commonly considered as a motor neuron
disease (MND) variant which almost exclusively affects upper motor neurons (UMN). There …

We modified the World Federation of Neurology (WFN) diagnostic criteria for ALS to facilitate
early diagnosis and used these criteria for enrollment of ALS patients in a clinical trial. The …

Aim To investigate whether primary lateral sclerosis (PLS) represents part of the
amyotrophic lateral sclerosis–frontotemporal dementia (ALS–FTD) spectrum of diseases …

Amyotrophic lateral sclerosis (ALS) is the most common adult‐onset motor neuron disorder
characterized by progressive degeneration of cortical, bulbar, and spinal motor neurons …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of
upper and lower motor neurons, leading to progressive loss of motor function. The disease …

Objective: To determine how clinical features at the first evaluation and in follow-up can be
used to suggest a diagnostic outcome for patients with only upper motor neuron (UMN) …

Amyotrophic lateral sclerosis, when viewed as a biological entity rather than a clinical
syndrome, probably evolves along a continuum, with the initial clinically silent phase …