Acute lung injury and acute respiratory distress syndrome (ARDS) are characterised by
severe hypoxemic respiratory failure and poor lung compliance. Despite advances in clinical …

Regardless of the cause, a common pathophysiological feature of patients with acute
respiratory distress syndrome is a dysfunction of the endogenous surfactant system …

Objectives To outline both the preclinical and clinical data demonstrating surfactant
alterations in acute lung injury, which provide the rationale for testing exogenous surfactant …

Surfactant therapy for acute lung injury/acute respiratory d... : Current Opinion in Critical
Care Surfactant therapy for acute lung injury/acute respiratory distress syndrome : Current …

The importance of pulmonary surfactant in maintaining normal lung function, and the
observations that alterations in endogenous surfactant contribute to the lung dysfunction …

Acute respiratory distress syndrome (ARDS) is often characterized by reduced lung
compliance, which suggests dysfunction of the endogenous surfactant system. The …

Rationale: Compositional changes in surfactant and/or decreased surfactant content of the
lungs are common features in patients with acute respiratory failure. Instillation of …

OBJECTIVE: To evaluate whether exogenous surfactant therapy may be useful in adult
patients with acute lung injury or acute respiratory distress syndrome, using a meta-analysis …

The efficacy of surfactant replacement therapy for pediatric and adult lung injuries has been
an ongoing area of investigation for more than 25 years. Surfactant therapy is lifesaving in …

The changes in the surfactant system of patients with acute lung injury and acute respiratory
distress syndrome form the rationale for the instillation of exogenous surfactant. There is …