Background: Extensive biochemical and biophysical changes of the pulmonary surfactant
system occur in the acute respiratory distress syndrome (ARDS). Methods: The effect of …

The integrity of the surfactant system of the lung is essential for normal breathing.
Decreasing the surface tension at the interface between alveoli and air ensures (a) …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are acute life-
threatening forms of hypoxemic respiratory failure. ALI/ARDS patients require intensive care …

Rationale Limited data are available on predictors for surfactant retreatment in preterm
infants with respiratory distress syndrome (RDS). Objective To study the pharmacokinetics of …

BACKGROUND Surfactant has been shown to be dysfunctional in ARDS, and exogenous
surfactant has proven effective in many forms of neonatal and pediatric acute lung injury …

Objective Treatment of preterm infants with respiratory distress syndrome (RDS) with
exogenous surfactant has greatly improved clinical outcome. Some infants require multiple …

Exogenous surfactant therapy is not standard in the acute respiratory distress syndrome
(ARDS) because of a lack of proven benefit. Nonuniform surfactant distribution after either …

Respiratory distress syndrome (RDS) in newborn neonates is characterised by deficient
secretion of surfactant from type III alveolar cells. Administration of surfactant to airways …

Objective: To investigate the efficacy of surfactant administration in a larger, more
homogenous population of children with lung injury/acute respiratory distress syndrome due …

Objective To investigate the acute effect of surfactant replacement in multiple-trauma
patients with lung contusion and acute lung injury. Design and setting Prospective …