Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps

D De Luca, P Cogo, MC Kneyber, P Biban, MG Semple… - Critical Care, 2021 - Springer
Pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome have
different age-specific characteristics and definitions. Trials on surfactant for ARDS in children …

Adult respiratory distress syndrome and artificial surfactant replacement in the pediatric patient

F PEREZ-BENAVIDES, E RIFF… - Pediatric emergency …, 1995 - journals.lww.com
Adult respiratory distress syndrome (ARDS) frequently develops after near-drowning, smoke
inhalation, burns, blunt trauma to chest, and overwhelming sepsis. Surfactant depletion …

Severe neonatal respiratory distress syndrome treated with the isolated phospholipid fraction of natural surfactant

G Noack, P Berggren, T Curstedt, G Grossmann… - Acta …, 1987 - Wiley Online Library
Ten newborn infants (795–1680 g) with severe respiratory distress syndrome (RDS) were
treated with the isolated phospholipid fraction of bovine or porcine surfactant, which was …

Comparison of clinical responses to natural and synthetic surfactants

M Rollins, J Jenkins, R Tubman, C Corkey, D Wilson - 1993 - degruyter.com
In recent years both natural and synthetic surfactants have been shown to be effective in
reducing mortality and morbidity in neonates with respiratory distress syndrome [1, 2, 4—24] …

Novel approaches to surfactant administration

S Gupta, SM Donn - Critical Care Research and Practice, 2012 - Wiley Online Library
Surfactant replacement therapy has been the mainstay of treatment for preterm infants with
respiratory distress syndrome for more than twenty years. For the most part, surfactant is …

Surfactant replacement therapy: an update on applications

SA Dekowski, RB Holtzman - Pediatric Clinics of North America, 1998 - Elsevier
Surfactant replacement therapy has been shown to be an effective and often life-saving
treatment for newborn infants with respiratory distress syndrome (RDS). Since the …

[HTML][HTML] A recipe for a good clinical pulmonary surfactant

J Pérez-Gil - biomedical journal, 2022 - Elsevier
The lives of thousands premature babies have been saved along the last thirty years thanks
to the establishment and consolidation of pulmonary surfactant replacement therapies …

Designer surfactants: the next generation in surfactant replacement

BA Holm, AJ Waring - Clinics in perinatology, 1993 - Elsevier
Exogenous surfactant replacement mixtures currently used for the prevention and treatment
of neonatal respiratory distress syndrome are either obtained from mammalian lungs or are …

Effects of ventilation strategies on the efficacy of exogenous surfactant therapy in a rabbit model of acute lung injury

Y ITO, SEE MANWELL, CL KERR… - American journal of …, 1998 - atsjournals.org
We evaluated the effects of various ventilation strategies on the efficacy of exogenous
surfactant therapy in lung-injured adult rabbits. Lung injury was induced by repetitive whole …

Strategies to protect surfactant and enhance its activity

D De Luca, C Autilio - biomedical journal, 2021 - Elsevier
The knowledge about surfactant biology is now deeper and recent research has allowed to
clarify its role in several human lung disorders. The balance between surfactant production …