Importance of the field: With the emergence of therapeutic candidates for the incurable and
rapidly progressive neurodegenerative condition of amyotrophic lateral sclerosis (ALS), it …

Objective markers of disease sensitive to the clinical activity, symptomatic progression, and
underlying substrates of neurodegeneration are highly coveted in amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder
which is incurable to date. As there are many ongoing studies with therapeutic candidates, it …

In patients with ALS, conventional MR imaging is frequently noninformative, and its use has
been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive …

Amyotrophic lateral sclerosis (ALS) is now recognised to be a heterogeneous
neurodegenerative syndrome of the motor system and its frontotemporal cortical …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which a precise
cause has not yet been identified. Standard CT or MRI evaluation does not demonstrate …

Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …

Amyotrophic lateral sclerosis as a system failure is a concept supported by the finding of
consistent extramotor as well as motor cerebral pathology. The functional correlates of the …

MRI and PET studies in ALS have consistently shown patterns of functional and structural
changes considered to be the pathological signature of the disease. The constant advance …

Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes
progressive muscle weakness and disability, eventually leading to death. Heterogeneity of …