Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study

A Astrup, S Rössner, L Van Gaal, A Rissanen… - The Lancet, 2009 - thelancet.com
Background The frequency of obesity has risen dramatically in recent years but only few
safe and effective drugs are currently available. We assessed the effect of liraglutide on …

A randomized, controlled trial of 3.0 mg of liraglutide in weight management

X Pi-Sunyer, A Astrup, K Fujioka… - … England Journal of …, 2015 - Mass Medical Soc
Background Obesity is a chronic disease with serious health consequences, but weight loss
is difficult to maintain through lifestyle intervention alone. Liraglutide, a glucagon-like …

Liraglutide for weight management: a critical review of the evidence

A Mehta, SP Marso, IJ Neeland - Obesity science & practice, 2017 - Wiley Online Library
Objective To review the efficacy, safety, and clinical applicability of liraglutide for weight
management from phase III clinical trials. Methods A search of the English language …

Liraglutide: a new option for the treatment of obesity

WA Nuffer, JM Trujillo - Pharmacotherapy: The Journal of …, 2015 - Wiley Online Library
Obesity continues to pose a major public health risk to the United States and across the
world, with an estimated one‐third of adult Americans being defined as obese. Obesity …

Efficacy of liraglutide for weight loss among patients with type 2 diabetes: the SCALE diabetes randomized clinical trial

MJ Davies, R Bergenstal, B Bode, RF Kushner… - Jama, 2015 - jamanetwork.com
Importance Weight loss of 5% to 10% can improve type 2 diabetes and related
comorbidities. Few safe, effective weight-management drugs are currently available …

Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide

A Astrup, R Carraro, N Finer, A Harper… - International journal of …, 2012 - nature.com
Objective: Having demonstrated short-term weight loss with liraglutide in this group of obese
adults, we now evaluate safety/tolerability (primary outcome) and long-term efficacy for …

Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled …

IJ Neeland, SP Marso, CR Ayers, B Lewis… - The lancet Diabetes & …, 2021 - thelancet.com
Background Visceral and ectopic fat are key drivers of adverse cardiometabolic outcomes in
obesity. We aimed to evaluate the effects of injectable liraglutide 3· 0 mg daily on body fat …

An evaluation of liraglutide including its efficacy and safety for the treatment of obesity

CH Lin, L Shao, YM Zhang, YJ Tu, Y Zhang… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: The prevalence of obesity is increasing worldwide and associated conditions,
particularly type 2 diabetes mellitus (T2DM), also show increasing prevalence. Lifestyle …

Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo …

TF Dejgaard, CS Frandsen, TS Hansen… - The lancet Diabetes & …, 2016 - thelancet.com
Background The combination of insulin and glucagon-like peptide-1 (GLP-1) receptor
agonist therapy improves glycaemic control, induces weight loss, and reduces insulin dose …

Tolerability of nausea and vomiting and associations with weight loss in a randomized trial of liraglutide in obese, non-diabetic adults

MEJ Lean, R Carraro, N Finer, H Hartvig… - International journal of …, 2014 - nature.com
Background: Liraglutide 3.0 mg, with diet and exercise, produced substantial weight loss
over 1 year that was sustained over 2 years in obese non-diabetic adults. Nausea was the …