Misra et al.(1971) found that 1 h after a single subcutaneous injection of [N-Me-l4C1-
morphine into the rat, three radioactive compounds could be extracted from the cerebral …

Formation of conjugated metabolites from morphine at a very low level in brain was studied
in vitro in rats. Incubation of a low concentration of 3H-morphine with brain homogenate …

Morphine has been determined in serum, cerebrospinal fluid (csf) and in five brain regions
in the rat after a single intravenous dose, using high performance liquid chromatography …

A method was recently developed by Raffa et al (1) for rapid analysis of brain levels of
morphine in rats given the drug subcutaneously. The technique combines the extraction …

Evidence for the specificity of the radioimmunoassay for morphine in plasma was provided
by demonstrating similar results with a fluorometric assay method which did not measure …

Materials and Methods Animals. The subjects were male Wistar rats (TNO, Zeist, the
Netherlands), weighing approximately 220 g. They were maintained in a temperature …

Rats were injected with morphine-6 (3) H diluted with increasing amounts of non-
radiolabelled morphine. The entry of the isotope into the brain and various tissues was …

Regional morphine accumulation was examined in 8 brain areas (cerebral cortex,
hippocampus, striatum, midbrain, hypothalamus, thalamus, medulla oblongata and …

抄録 In the previous study of this series, morphine was shown to be metabolized not only to
morphine-3-glucuronide, but also to morphine-6-glucuronide in rabbits. The present study …

The role played by the active or passive transport of narcotic analgesics in the action of
these drugs on the central nervous system is not clear. Choroid plexus tissue in vitro …