An assessment of the potential cross-reactivity of levo-alpha-acetylmethadol (LAAM) with urine assays for methadone

PJ Fudala, E Yu, K Kampman - Journal of Maintenance in the …, 1997 - Taylor & Francis
Levo-alpha-acetylmethadol (LAAM), also known as levomethadyl acetate, was recently
approved by the Food and Drug Administration for the management of opiate dependence …

Relative potency of levo-α-Acetylmethadol and methadone in humans under acute dosing conditions

T Eissenberg, ML Stitzer, GE Bigelow… - … of Pharmacology and …, 1999 - ASPET
levo-α-Acetylmethadol (LAAM) and methadone are full μ-opioid agonists used to treat opioid
dependence. Current labeling indicates that LAAM is less potent than methadone. Clinical …

Levomethadyl acetate (LAAM) for the treatment of opioid dependence: a multisite, open-label study of LAAM safety and an evaluation of the product labeling and …

PJ Fudala, F Vocci, A Montgomery… - … of Maintenance in the …, 1998 - Taylor & Francis
Levomethadyl Acetate (LAAM) for the Treatment of Opioid Dependence: A Multisite, Open-Label
Study of LAAM Safety and an Evaluati Page 1 Levomethadyl Acetate (LAAM) for the …

The use of levo-alpha-acetylmethadol (LAAM) in methadone patients who have not achieved heroin abstinence

L Borg, A Ho, A Wells, H Joseph, P Appel… - Journal of addictive …, 2002 - Taylor & Francis
Abstract Levo-alpha-acetylmethadol (LAAM) pharmacotherapy was offered to twelve
patients who continued illicit opioid abuse after> eleven months in methadone maintenance …

[PDF][PDF] Phase III clinical study of LAAM: report of current status and analysis of early terminations

JA Whysner, GL Levine - The International Challenge of Drug …, 1978 - archives.nida.nih.gov
Levo-alpha-acetylmethadol (LAAM) is under investigation for maintenance therapy of
persons addicted to opiate drugs. Jaffe et al.(5, 6, 7) reported that LAAM was successful as a …

Detection of methadone, LAAM, and their metabolites by methadone immunoassays

ML Cheever, GA Armendariz… - Journal of analytical …, 1999 - academic.oup.com
Abstract l-α-Acetylmethadol (LAAM) was recently approved as a substitute for methadone.
LAAM, methadone, and their common metabolite, methadol, are extensively N …

Determination of l-α-acetylmethadol (LAAM), norLAAM, and dinorLAAM in clinical and in vitro samples using liquid chromatography with electrospray ionization and …

W Huang, PA Bemis, MH Slawson… - Journal of pharmaceutical …, 2003 - Elsevier
ABSTRACT l-α-Acetylmethadol (LAAM) is an alternative to methadone for the maintenance
treatment of opioid dependence. LAAM has a longer therapeutic half-life than methadone …

An examination of the pharmacodynamics and pharmacokinetics of Levo-alpha-acetylmethadol (LAAM), compared to methadone, in opioid maintenance patients

DAL Newcombe - 2006 - hekyll.services.adelaide.edu.au
Methadone is currently the most widely used agent to manage opioid dependence, but
clinical experience has highlighted some limitations with its use. In particular, a relatively …

1-α-Acetylmethadol (LAAM) pharmacokinetics and metabolism: current status

AL Misra, SJ Mule - The American Journal of Drug and Alcohol …, 1975 - Taylor & Francis
LAAM) is a synthetic congener [1, 21 of methadone. The presence of two asymmetric carbon
atoms in the molecule gives rise to two diastereoisomeric pairs [3] a and 0, of which the a …

Dose-related efficacy of levomethadyl acetate for treatment of opioid dependence: a randomized clinical trial

T Eissenberg, GE Bigelow, EC Strain, SL Walsh… - Jama, 1997 - jamanetwork.com
Objective.—To compare the clinical efficacy of different doses of levomethadyl acetate
hydrochloride (known as LAAM) in the treatment of opioid dependence. Design.—A …