Primary lateral sclerosis (PLS) is a disorder of progressive upper motor neuron dysfunction,
in the absence of clinical signs of lower motor neuron involvement or family history …

Primary lateral sclerosis (PLS) is a rare degenerative disorder of the upper motor neuron. Its
nosological status and relationship to other motor neuron syndromes, especially …

Primary lateral sclerosis (PLS) is a rare neurodegenerative disorder at the upper motor
neurone extreme of the spectrum of motor neurone disease. The diagnosis is clinical and …

Primary lateral sclerosis (PLS) has been defined as a rare. Non-hereditary disease
characterized by progressive spinobulbar spasticity, related to the exclusive involvement of …

Objective: To determine identifiable subgroups of patients with primary lateral sclerosis
(PLS) with distinct clinical features as a first step in identifying patients likely to have the …

Objective: The objective of this study was to characterize the clinical features and natural
history of primary lateral sclerosis (PLS). Background: PLS is a motor neuron disorder …

Abstract Primary Lateral Sclerosis (PLS) is an uncommon motor neuron disorder. Despite
the well-recognisable constellation of clinical manifestations, the initial diagnosis can be …

The question of whether primary lateral sclerosis (PLS) is a nosological entity distinct from
amyotrophic lateral sclerosis (ALS) has been the subject of controversy since it was first …

Objective To assess whether primary lateral sclerosis (PLS), classified as pure when the
EMG is normal, converts to amyotrophic lateral sclerosis (ALS) after longitudinal follow-up …

Objective: To understand phenotypic and molecular characteristics of patients with clinically
“definite” primary lateral sclerosis (PLS) in a prospective study. Methods: Six sites enrolled …