Introduction Primary lateral sclerosis is a rare neurodegenerative disorder of the upper
motor neurons. Diagnostic criteria have changed considerably over the years, and the …

Background Primary lateral sclerosis is a progressive upper-motor-neuron disorder
associated with markedly longer survival than ALS. In contrast to ALS, the genetic …

Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system.
Characterised by a slowly progressive upper motor neuron syndrome, the diagnosis is …

Objectives Primary lateral sclerosis (PLS) is commonly considered as a motor neuron
disease (MND) variant which almost exclusively affects upper motor neurons (UMN). There …

Primary lateral sclerosis (PLS) is an adult-onset upper motor neuron disease manifesting in
progressive spasticity and gradually resulting in considerably motor disability. In the …

[Primary lateral sclerosis: the era of international diagnosis criteria]. - Abstract - Europe PMC Sign
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Abstract Primary Lateral Sclerosis (PLS) is an uncommon motor neuron disorder. Despite
the well-recognisable constellation of clinical manifestations, the initial diagnosis can be …

There is still a debate whether primary lateral sclerosis (PLS) is a distinct pathological entity
or whether it represents one end of a continuous spectrum of motor neuron disease (MND) …

Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …

Objective: To determine identifiable subgroups of patients with primary lateral sclerosis
(PLS) with distinct clinical features as a first step in identifying patients likely to have the …