Pharmacokinetic (PK) and pharmacodynamic (PD) data were available from a study of a
nasal delivery system for the opioid analgesic fentanyl, together with data on the kinetics of …

Traditionally, physiological pharmacokinetic models assume that arterial blood flow to tissue
is the rate-limiting step in the transfer of drug into tissue parenchyma. When this assumption …

Background. The factors affecting the concentrations of fentanyl in the brain after
intravenous administration have not been completely quantified. Methods. A model …

The objectives of this investigation were to characterize the disposition of fentanyl and
alfentanil in 14 tissues in the rat, and to create physiological pharmacokinetic models for …

The authors compared the population pharmacokinetics of fentanyl using a standard
individualized modeling (SIM) approach versus that of a nonparametric expectation …

Abstract Provisional Advisory Levels (PALs) are tiered exposure limits for toxic chemicals in
air and drinking water that are developed to assist in emergency responses. Physiologically …

Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric
populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as …

Physiologically based pharmacokinetic (PBPK) models can be used to predict drug
disposition in humans from animal data and the influence of disease or other changes in …

This thesis concerns two investigations into the opioid analgesic fentanyl. The first is a
clinical investigation into the safety and efficacy of fentanyl administered by inhalation. The …

Background The influence of changes in the physiologic state of a patient on the disposition
of fentanyl and alfentanil is poorly understood. The aims of this study were to determine …