Objective: Amyotrophic lateral sclerosis (ALS) is a clinically heterogenous disease, typically
presenting with focal motor weakness that eventually generalizes. Weather there is a …

MRI has emerged as one of several urgently needed candidate disease progression
biomarkers for the neurodegenerative disorder amyotrophic lateral sclerosis (ALS), not least …

Objective: To describe the patterns of cortical and subcortical changes in amyotrophic lateral
sclerosis (ALS) stratified for the C9orf72 genotype. Methods: A prospective, single-center …

Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …

BACKGROUND AND PURPOSE: Primary lateral sclerosis (PLS) is a rare form of motor
neuron disease characterized by upper motor neuron dysfunction. Because pathologic …

Background Body region of onset and functional disability are key components of disease
heterogeneity in amyotrophic lateral sclerosis (ALS). Objectives To evaluate patterns of grey …

Background: Primary lateral sclerosis (PLS) is a rare neurodegenerative disease that affects
the upper motor neurons of the CNS. Juvenile-onset PLS (JPLS) is inherited in an …

Positron emission tomography was used to measure regional cerebral blood flow (rCBF) in
12 patients with amyotrophic lateral sclerosis (ALS) and six age-matched controls. Scans …

The overlap of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) has
been well documented in FTD patients with co-morbid motor neuron degeneration and in …

Despite an early understanding of amyotrophic lateral sclerosis (ALS) as a disease affecting
the motor system, including motoneurons in the motor cortex, brainstem, and spinal cord …