Left atrial appendage shape impacts on the left atrial flow hemodynamics: a numerical hypothesis generating study on two cases

L Alinezhad, F Ghalichi, M Ahmadlouydarab… - Computer Methods and …, 2022 - Elsevier
Background and objectives The left atrial appendage (LAA) is the most common region for
thrombus formation in atrial fibrillation (AF). Morphological parameters such as shape, size …

Computational modeling of hemodynamics and risk of thrombosis in the left atrial appendage using patient-specific blood viscosity and boundary conditions at the …

Z Zhang, J Zhu, M Wu, M Neidlin, WT Wu… - … and Modeling in …, 2023 - Springer
Hemodynamics play a vital role for the risk of thrombosis in the left atrial appendage (LAA)
and left atrium (LA) for patients with atrial fibrillation. Accurate prediction of hemodynamics in …

Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage

G García‐Isla, AL Olivares, E Silva… - … journal for numerical …, 2018 - Wiley Online Library
The left atrial appendage (LAA) is a complex and heterogeneous protruding structure of the
left atrium (LA). In atrial fibrillation patients, it is the location where 90% of the thrombi are …

[HTML][HTML] Evaluation of stroke risk in patients with atrial fibrillation using morphological and hemodynamic characteristics

L Wang, Z Wang, R Fang, ZY Li - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Background: It is well known that the thrombus triggering stroke in patients with atrial
fibrillation (AF) mainly comes from the left atrial appendage (LAA). This study aims to …

Joint analysis of morphological parameters and in silico haemodynamics of the left atrial appendage for thrombogenic risk assessment

MI Pons, J Mill, A Fernandez-Quilez… - Journal of …, 2022 - Wiley Online Library
Background. Atrial fibrillation (AF) is considered the most common human arrhythmia. In
nonvalvular AF, around 99% of thrombi are formed in the left atrial appendage (LAA) …

Stroke risk evaluation for patients with atrial fibrillation: Insights from left atrial appendage with fluid-structure interaction analysis

R Fang, Z Wang, X Zhao, J Wang, Y Li, Y Zhang… - Computers in Biology …, 2022 - Elsevier
The majority of cardioembolic strokes in patients with non-valvular atrial fibrillation (NVAF)
are resulted from clot formation in the left atrial appendage (LAA). Current stroke risk …

A computational framework for personalized blood flow analysis in the human left atrium

T Otani, A Al-Issa, A Pourmorteza, ER McVeigh… - Annals of biomedical …, 2016 - Springer
Atrial fibrillation (AF), the most common human arrhythmia, is a marker of an increased risk
of embolic stroke. However, recent studies suggest that AF may not be mechanistically …

In-silico analysis of the influence of pulmonary vein configuration on left atrial haemodynamics and thrombus formation in a large cohort

J Mill, J Harrison, B Legghe, AL Olivares… - … on Functional Imaging …, 2021 - Springer
Atrial fibrillation (AF) is considered the most common human arrhythmia. Around 99% of
thrombi in non-valvular AF are formed in the left atrial appendage (LAA). Studies suggest …

[HTML][HTML] Inversion of left atrial appendage will cause compressive stresses in the tissue: Simulation study of potential therapy

S Pasta, JM Guccione, GS Kassab - Journal of Personalized Medicine, 2022 - mdpi.com
In atrial fibrillation (AF), thromboembolic events can result from the particular conformation of
the left atrial appendage (LAA) bearing increased clot formation and accumulation. Current …

Boundary-condition analysis of an idealized left atrium model

J Dueñas-Pamplona, J Sierra-Pallares, J García… - Annals of Biomedical …, 2021 - Springer
The most common type of cardiac arrhythmia is atrial fibrillation (AF), which is characterised
by irregular and ineffective atrial contraction. This behaviour results into the formation of …