BACKGROUND AND PURPOSE: The extensive application of advanced MR imaging
techniques to the study of ALS has undoubtedly improved our knowledge of disease …

Background White matter (WM) impairment is a hallmark of amyotrophic lateral sclerosis
(ALS). This study evaluated the capacity of mean apparent propagator magnetic resonance …

Background The results of recent diffusion tensor imaging (DTI) studies on amyotrophic
lateral sclerosis (ALS) are inconclusive and controversial. We performed a voxel-based …

Previous neuroimaging studies have revealed that both gray matter (GM) and white matter
(WM) are altered in several morphological aspects in amyotrophic lateral sclerosis (ALS) …

Objectives To assess microstructural alterations in white matter (WM) in amyotrophic lateral
sclerosis (ALS) using diffusion tensor imaging (DTI). Methods DTI data were collected from …

Amyotrophic lateral sclerosis (ALS) is characterized primarily by motor neuron but also
frontotemporal lobar degeneration. Although the cerebellum is involved in both motor and …

BACKGROUND AND PURPOSE: Most DTI studies in ALS have been limited to the
assessment of the CST damage. In this study, we used DTI tractography to investigate …

Objective To evaluate progressive white matter (WM) degeneration in amyotrophic lateral
sclerosis (ALS). Methods Sixty-six patients with ALS and 43 healthy controls were enrolled …

The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients
show structural changes within but also beyond the motor cortex and corticospinal tract and …

BACKGROUND AND PURPOSE: ALS leads to macrostructural (ie, cortical atrophy and
hyperintensities along the corticospinal tract) and microstructural (ie, gray matter intrinsic …